Squamous cell skin cancer
Squamous-cell skin cancer, also known as cutaneous squamous-cell carcinoma (cSCC), is one of the main types of skin cancer along with basal cell cancer, and melanoma.[10] It usually presents as a hard lump with a scaly top but can also form an ulcer.[1] Onset is often over months.[4] Squamous-cell skin cancer is more likely to spread to distant areas than basal cell cancer.[11]
The greatest risk factor is high total exposure to ultraviolet radiation from the Sun.[2] Other risks include prior scars, chronic wounds, actinic keratosis, lighter skin, Bowen’s disease, arsenic exposure, radiation therapy, poor immune system function, previous basal cell carcinoma, and HPV infection.[2][12] Risk from UV radiation is related to total exposure, rather than early exposure.[13] Tanning beds are becoming another common source of ultraviolet radiation.[13] It begins from squamous cells found within the skin.[14] Diagnosis is often based on skin examination and confirmed by tissue biopsy.[2][3]
Decreasing exposure to ultraviolet radiation and the use of sunscreen appear to be effective methods of preventing squamous-cell skin cancer.[5][6] Treatment is typically by surgical removal.[2] This can be by simple excision if the cancer is small otherwise Mohs surgery is generally recommended.[2] Other options may include application of cold and radiation therapy.[7] In the cases in which distant spread has occurred chemotherapy or biologic therapy may be used.[7]
As of 2015, about 2.2 million people have cSCC at any given time.[8] It makes up about 20% of all skin cancer cases.[15] About 12% of males and 7% of females in the United States developed cSCC at some point in time.[2] While prognosis is usually good, if distant spread occurs five-year survival is ~34%.[4][5] In 2015 it resulted in about 51,900 deaths globally.[9] The usual age at diagnosis is around 66.[4] Following the successful treatment of one case of cSCC people are at high risk of developing further cases.[2]
Norman
Norman /ˈnɔːrmən/ is a city in the U.S. state of Oklahoma 20 miles (30 km) south of downtown Oklahoma City in its metropolitan area. The population was 110,925 at the 2010 census.[1] Norman’s estimated population of 120,284 in 2015 makes it the third-largest city in Oklahoma, and the city serves as the county seat of Cleveland County.
Norman was settled during the Land Run of 1889, which opened the former Unassigned Lands of Indian Territory to American pioneer settlement. The city was named in honor of Abner Norman, the area’s initial land surveyor, and was formally incorporated on May 13, 1891. Economically the city has prominent higher education and related research industries, as it is the home to the University of Oklahoma, the largest university in the state, with approximately 30,000 students enrolled. The university is well known for its sporting events by teams under the banner of the nickname “Sooners,” with over 80,000 people routinely attending football games. The university is home to several museums, including the Fred Jones Jr. Museum of Art, which contains the largest collection of French Impressionist art ever given to an American university, as well as the Sam Noble Oklahoma Museum of Natural History.
The National Weather Center, located in Norman, houses a unique collection of university, state, federal, and private sector organizations that work together to improve the understanding of events related to the Earth’s atmosphere. Norman lies within Tornado Alley, a geographic region where tornadic activity is particularly frequent and intense. The Oklahoma City metropolitan area, including Norman, is the most tornado-prone area in the world. The Storm Prediction Center (SPC), a branch of the National Oceanic and Atmospheric Administration (NOAA) is located at the NWC. SPC forecasts severe storm and tornado outbreaks nationwide. Additionally, research is conducted at the co-located National Severe Storms Laboratory (NSSL), which includes field research and operates various experimental weather radars.
In 2008, CNN‘s Money Magazine ranked Norman as the sixth best small city within the United States to live in.